BS-181 hydrochloride

CAS No. 1397219-81-6

BS-181 hydrochloride ( BS181 )

Catalog No. M11657 CAS No. 1397219-81-6

BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 40 In Stock
5MG 65 In Stock
10MG 115 In Stock
25MG 259 In Stock
50MG 430 In Stock
100MG 620 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    BS-181 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM.
  • Description
    BS-181 is a potent, selective CDK7 inhibitor with IC50 of 21 nM, 40-fold selectivity over CDK2/cycE and no significant activity against CDK1/cycB, CDK4/cycD1, CDK5/p35NCK, CDK6/cycD1, and CDK9/cycT (IC50>1 uM); promotes cell cycle arrest and inhibits cancer cell growth in a panel of cell lines representing a range of tumor types (IC50=1.5 to 37 uM), inhibits the phosphorylation of CDK7 substrates, inhibits phosphorylation of the RNA polymerase II COOH-terminal domain (CTD) at P-Ser5 (IC50=9 uM), inhibits RB phosphorylation at Ser795 and Ser821 (IC50=15 uM); induces apoptosis in vitro, and shows antitumor effects in vivo.
  • Synonyms
    BS181
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK7
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1397219-81-6
  • Formula Weight
    417.00
  • Molecular Formula
    C22H33ClN6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    Cl.CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1 |c:3,21,23,28,t:5,15,19|
  • Chemical Name
    Pyrazolo[1,5-a]pyrimidine-5,7-diamine, N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ali S, et al. Cancer Res. 2009 Aug 1;69(15):6208-15.
2. Kelso TW, et al. Mol Cell Biol. 2014 Oct 1;34(19):3675-88.
3. Wang BY, et al. Drug Des Devel Ther. 2016 Mar 16;10:1181-9.
4. Li B, et al. Cancer Res. 2017 Jul 15;77(14):3834-3845.
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